Unassociated Document

CUSIP No. 37250B14

SCHEDULE 13G

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1. Names of Reporting Persons:

FinSirton S.p.A.

I.R.S. Identification Nos. of above persons (entities only).

Not applicable

2. Check the Appropriate Box if a Member of a Group (See Instructions)

(a) ¨

(b) x

3. SEC Use Only

4. Citizenship or Place of Organization: Italy

Number of Shares Beneficially Owned by Each Reporting Person With:	5. Sole Voting Power: 0 (See Item 4)
	6. Shared Voting Power: 3,550,000 (See Item 4)
	7. Sole Dispositive Power: 0 (See Item 4)
	8. Shared Dispositive Power: 3,550,000 (See Item 4)

9. Aggregate Amount Beneficially Owned by Each Reporting Person: 3,550,000

10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) x

11. Percent of Class Represented by Amount in Row (9): 23.7%

12. Type of Reporting Person (See Instructions): CO

CUSIP No. 37250B14

SCHEDULE 13G

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1. Names of Reporting Persons:

Dr. Laura Ferro

I.R.S. Identification Nos. of above persons (entities only).

Not applicable

2. Check the Appropriate Box if a Member of a Group (See Instructions)

(a) ¨

(b) x

3. SEC Use Only

4. Citizenship or Place of Organization: Italy

Number of Shares Beneficially Owned by Each Reporting Person With:	5. Sole Voting Power: 60,000 (See Item 4)
	6. Shared Voting Power: 3,550,000 (See Item 4)
	7. Sole Dispositive Power: 60,000 (See Item 4)
	8. Shared Dispositive Power: 3,550,000 (See Item 4)

9. Aggregate Amount Beneficially Owned by Each Reporting Person: 3,610,000 (See Item 4)

10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) x

11. Percent of Class Represented by Amount in Row (9): 24.1%

12. Type of Reporting Person (See Instructions): IN

CUSIP No. 37250B14

SCHEDULE 13G

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This Amendment No. 4, jointly filed by FinSirton S.p.A. and Dr. Laura Ferro pursuant to Rule 13d-1(k) promulgated by the Securities and Exchange Commission pursuant to Section 13 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), amends the Schedule 13G filed with the Securities and Exchange Commission (the “SEC”) on February 16, 2010 with respect to the ordinary shares, no par value (the “Ordinary Shares”), of Gentium S.p.A.

Item 1.

(a) Name of Issuer: Gentium S.p.A. (“Gentium”).

(b) Address of Issuer’s Principal Executive Offices: Piazza XX Settembre 2, 20079 Villa Guardia (Como), Italy.

Item 2.

Item 2 of the Schedule 13G is hereby amended and restated in its entirety as follows:

(a) Name of Person Filing:

(i) FinSirton S.p.A. (“FinSirton”), an Italian joint stock company, by virtue of its direct ownership of 3,550,000 outstanding Ordinary Shares as of the date of this Statement; and

(ii) Dr. Laura Ferro (“Dr. Ferro”), an Italian citizen, by virtue of her direct beneficial ownership of 60,000 Ordinary Shares as of the date of this Statement, and deemed control over FinSirton as described in Item 4;

who are collectively referred to as the “Reporting Persons.” The Reporting Persons have entered into a Joint Filing Agreement, dated February 14, 2006, a copy of which has been previously filed and is hereby incorporated by reference, pursuant to which the Reporting Persons have agreed to file this Statement, and amendments hereto, jointly in accordance with the provisions of Rule 13d-1(k)(1) under the Exchange Act.

Pursuant to Rule 13d-4 of the Exchange Act, the Reporting Persons expressly declare that the filing of this Statement shall not be construed as an admission that either of them is, for the purposes of Section 13(d) and/or Section 13(g) of the Exchange Act or otherwise, the beneficial owner of any securities covered by this Statement held by any other person.

(b) Address of Principal Business Office or, if none, Residence: The address of the principal business office of each of the Reporting Persons is Piazza XX Settembre 2, 20079 Villa Guardia (Como), Italy.

(d) Title of Class of Securities: Ordinary Shares.

(e) CUSIP Number: 37250B14.

Item 3. If this statement is filed pursuant to §§240.13d-l(b) or 240.13d-2(b) or (c), check whether the person filing is a:

(a) ¨

Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).

(b) ¨

Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).

(d) ¨

Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).

(e) ¨

An investment adviser in accordance with §240.13d-l(b)(l)(ii)(E);

(f) ¨

An employee benefit plan or endowment fund in accordance with §240.13d-l(b)(l)(ii)(F);

(g) ¨

A parent holding company or control person in accordance with § 240.13d-l(b)(l)(ii)(G);

(h) ¨

A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

CUSIP No. 37250B14

SCHEDULE 13G

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(i) ¨

A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j) ¨

Group, in accordance with §240.13d-l(b)(l)(ii)(J).

Not applicable.

Item 4. Ownership.

Item 4 of the Schedule 13G is hereby amended and restated in its entirety as follows:

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

(a) Amount beneficially owned: As of the date of this Statement, FinSirton owns 3,550,000 Ordinary Shares. Dr. Ferro may be deemed to control FinSirton by virtue of her 33% ownership interest in FinSirton, and, accordingly, Dr. Ferro may be deemed to beneficially own the Ordinary Shares owned by FinSirton In addition, as of the date of this Statement, Dr. Ferro owns 60,000 Ordinary Shares. Dr. Ferro disclaims beneficial ownership of the Ordinary Shares owned by FinSirton.

FinSirton entered into a loan agreement with Intesa San Paolo S.p.A. (the “Intesa Loan Agreement”) on June 12, 2007. In connection with the Intesa Loan Agreement, FinSirton pledged 700,000 and 2,300,000 of its Ordinary Shares to Intesa San Paolo S.p.A. (“Intesa”) on June 12, 2007 and July 3, 2008, respectively.

(b) Percent of class:

(i) FinSirton: 23.7%

(ii) Dr. Ferro: 24.1% (after giving effect to the Ordinary Shares held by FinSirton that Dr. Ferro may be deemed to beneficially own, as described above)

(i) Sole power to vote or to direct the vote: Dr. Ferro has the sole power to vote or to direct the vote of 60,000 Ordinary Shares as of the date of this Statement.

(ii) Shared power to vote or to direct the vote: Dr. Ferro and FinSirton may be deemed to share the power to vote or to direct the vote of 3,550,000 Ordinary Shares owned by FinSirton as of the date of this Statement. Dr. Ferro disclaims such shared power to vote or to direct the vote of Ordinary Shares owned by FinSirton.

(iii) Sole power to dispose or to direct the disposition of: Dr. Ferro has the sole power to dispose or to direct the disposition of 60,000 Ordinary Shares as of the date of this Statement.

(iv) Shared power to dispose or to direct the disposition of: Dr. Ferro and FinSirton may be deemed to share the power to dispose or to direct the disposition of 3,550,000 Ordinary Shares owned by FinSirton as of the date of this Statement. Dr. Ferro disclaims such shared power to dispose or to direct the disposition of Ordinary Shares owned by FinSirton.

The Reporting Persons may be deemed to share the power to dispose or to direct the disposition of 3,000,000 Ordinary Shares owned by FinSirton and pledged to Intesa in connection with the Intesa Loan Agreement. The Reporting Persons disclaim sharing such power with Intesa.

Item 5. Ownership of Five Percent or Less of a Class

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following: o.

Not applicable.

CUSIP No. 37250B14

SCHEDULE 13G

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Item 6. Ownership of More than Five Percent on Behalf of Another Person.

Not applicable.

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company

Not applicable.

Item 8. Identification and Classification of Members of the Group

Not applicable.

Item 9. Notice of Dissolution of Group

Not applicable.

Item 10. Certification

Not applicable.

CUSIP No. 37250B14

SCHEDULE 13G

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SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: February 14, 2011

FINSIRTON S.p.A.

By:	/s/ Angelo Aredi Butti
	Name: Angelo Aredi Butti
	Title: Managing Director

/s/ Laura Ferro
Dr. Laura Ferro

	37250B14
(CUSIP Number)